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Cat No. | Product Name | Synonyms | Targets |
---|---|---|---|
T14988 | CMPD1 | MAPK | |
CMPD1 is a non-ATP-competitive p38 MAPK-mediated MK2 phosphorylation inhibitor(apparent Ki (Kiapp): 330 nM). | |||
T16501 | PF-3644022 | p38 MAPK , Serine Protease , MAPK | |
PF-3644022 is an effective, selective, and ATP-competitive MAPKAPK2 (MK2) inhibitor (IC50: 5.2 nM and a Ki of 3 nM). PF-3644022 potently inhibits TNFα production and has an anti-inflammatory effect. PF-3644022 also inhib... | |||
T12058 | MK2-IN-3 hydrate | MK-2 Inhibitor III | ERK , MAPK , MNK |
MK2-IN-3 hydrate (MK-2 Inhibitor III) is an orally active, selective, and ATP-competitive inhibitor of MAPKAP-K2 (MK-2) (IC50 of 0.85 nM) | |||
T9034 | MK2-IN-3 | MK2 Inhibitor III | MAPK |
MK2-IN-3 (MK2 Inhibitor III) is a potent, cell-permeable inhibitor of mitogen-activated protein kinase-activated protein kinase 2 (MAPKAP-K2 or MK-2) and can be used for the treatment of rheumatoid arthritis | |||
T15250 | ETC-206 | MNK | |
ETC-206 is a selective inhibitor of MNK1 and MNK2 (IC50s: 64 nM and 86 nM). | |||
T4442 | MK2-IN-1 hydrochloride | MK2 Inhibitor,MK 25 | MAPK |
MK2-IN-1 hydrochloride (MK 25) is a highly selective, non-ATP competitive inhibitor of p38/mitogen-activated protein kinase-activated protein kinase 2 (MAPKAPK2 or MK2, IC50: 0.11 μM) [1]. | |||
T6152 | PD318088 | MEK | |
PD318088 is a non-ATP competitive allosteric MEK1/2 inhibitor, binding simultaneously with ATP in a region of the MEK1 active site that is adjacent to the ATP-binding site. | |||
T6785 | BI-847325 | Apoptosis , MEK , Aurora Kinase | |
BI-847325 is a selective dual inhibitor of MEK and aurora kinases (AK) with IC50 values of 4 and 15 nM for human MEK2 and AK-C, respectively. | |||
T3468 | Tomivosertib | eFT508 | MNK , PD-1/PD-L1 |
Tomivosertib (eFT508) is a potent, highly selective MNK1 and MNK2 inhibitor with IC50 value of 1-2 nM. | |||
T80062 | Mitogen-activated protein kinase 1 | MAPK1 | NF-κB |
Mitogen-activated protein kinase 1 (MAPK1) activates the p38/NF-κB pathway and regulates cellular processes in sepsis-associated diseases. Its catalytic action phosphorylates substrate proteins, serving as a regulatory s... | |||
T21980 | PD 198306 | MEK | |
PD 198306 is a selective inhibitor of MAPK/ERK-kinase (MEK) with antihyperalgesic effects. PD 198306 reduces the Streptozocin-induced increase in the level of active ERK1. | |||
T6692 | TAK-733 | TAK733,TAK 733 | MEK |
TAK-733 is an orally bioavailable small-molecule inhibitor of MEK1 and MEK2 (MEK1/2) with potential antineoplastic activity. | |||
T2708 | SL327 | SL 327,SL-327 | MEK , DNA/RNA Synthesis |
SL327 is a selective inhibitor for MEK1/2 with IC50 of 0.18 μM/0.22 μM; able to transport through the blood-brain barrier. | |||
T21295 | BIX02189 | BIX 02189 | ERK , MEK |
BIX02189 is a potent and selective inhibitor of MEK5 and ERK5(IC50 : 1.5 nM and 59 nM). | |||
T21635 | PD184161 | MEK | |
PD184161 is a novel, orally-active MEK inhibitor. PD184161 inhibited MEK activity (IC50 = 10-100 nM) in a time- and concentration-dependent manner[1]. | |||
T4424 | SLV-2436 | SEL-201,SLV 2436,SEL201-88 | MNK |
SLV-2436 (SEL201-88) is a novel effective and ATP-competitive inhibitor of MNK1 and MNK2 (IC50: 10.8/5.4 nM). | |||
T2378 | RGB-286638 free base | GSK-3 , MEK , JAK , CDK | |
RGB-286638 free base is a novel CDK inhibitor with IC50s of 1 nM/2 nM/3 nM/4 nM/5 nM for cyclin T1-CDK9/cyclin B1-CDK1/cyclin E-CDK2/cyclin D1-CDK4/cyclin E-CDK3/p35-CDK5 respectively; less potent against cyclin H-CDK7 a... | |||
TMS2181 | Trans-Zeatin | (E)-Zeatin | ERK , MEK , Endogenous Metabolite |
trans-Zeatin ((E)-Zeatin) is the member of the plant growth hormone family known as cytokinins, which regulate cell division, development, and nutrient processing. | |||
T2443 | CI-1040 | PD 184352 | Apoptosis , MEK |
CI-1040 (PD 184352) (PD184352) is an ATP non-competitive MEK1/2 inhibitor (IC50: 17 nM). | |||
T6440 | CGP 57380 | MNK1 Inhibitor | Apoptosis , MNK |
CGP 57380 (MNK1 Inhibitor) is a potent MNK1 inhibitor with IC50 of 2.2 μM, exhibiting no inhibitory activity on p38, JNK1, ERK1 and -2, PKC, or c-Src-like kinases. |